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# thetntlab.com

Intelligent Neurotechnologies for Translation in Medicine

## Sitemaps

- [XML Sitemap](https://thetntlab.com/sitemap.xml): Contains all public & indexable URLs for this website.

## Pages

- [Home Page](https://thetntlab.com/) - Intelligent Neurotechnologies for Translation in Medicine Transforming neurotechnology through science, feedback control, and clinical translation. Led by Dr. Rosana Esteller Meet Our Team Explore Our Research What We Do The Translational NeuroTechnology Lab at the University of Minnesota develops next-generation neurotechnologies that sense, interpret, and respond to the nervous system. We focus on translating rigorous
- [Research Applicant Page](https://thetntlab.com/research-applicant-page/) - Overview Eligibility FAQ Interest Form Hamburger Toggle Menu Actively Recruiting Study: SEAS Study (Sensory Engagement and Activation Stimulation) We are recruiting healthy volunteers to help us explore how the brain responds to noninvasive stimulation. If you are interested, please review the study information and eligibility criteria and complete the interest form below.Why participate? This study focuses
- [Team](https://thetntlab.com/team/) - The Team Principal Investigator, TNT Lab Director Dr. Rosana Esteller Professor, Biomedical Engineering Department, University of Minnesota Professor Esteller has a strong track record of translating innovative medical devices from concept to clinical use. She played a pivotal role in developing the world’s first closed-loop, brain-implantable neuromodulation device—enabled by her biomarker detection algorithms—now commercially available
- [Contact Us](https://thetntlab.com/contact-us/) - Get In Touch With Us Collaborating/Partnering with us: We work with industry teams to translate new neurotechnologies from concept to clinical validation. Our core capabilities include: Biomarker DiscoveryComputational Modeling Closed-loop control Smart clinical and preclinical (animal) trials Innovate Together Join Us in Advancing Neuroscience Interested in.... joining as a lab researcher? participating in a clinical study? collaborating
- [Research Applicant Page - SSB Edit Old](https://thetntlab.com/research-applicant-page-ssb-edit/) - Overview Eligibility FAQ Interest Form Hamburger Toggle Menu About Our Research Our lab conducts human-subject research aimed at advancing neurotechnology and biomedical science. We regularly recruit healthy volunteers for approved research studies at the University of Minnesota. Participation is always voluntary, and all studies are reviewed and approved by the University’ Institutional Review Board (IRB).
- [Research Applicant Page Old](https://thetntlab.com/elementor-page-1632/) - Overview Eligibility FAQ Interest Form Hamburger Toggle Menu About Our Research Our lab conducts human-subject research aimed at advancing neurotechnology and biomedical science. We regularly recruit healthy volunteers for approved research studies at the University of Minnesota. Participation is always voluntary, and all studies are reviewed and approved by the University’ Institutional Review Board (IRB).
- [Facilities](https://thetntlab.com/facilities/) - World-Class Facilities Translational NeuroTechnology Lab Core Facility Over 1,000 sq. ft. of dedicated research space exclusively for the NeuroTrans Lab, designed for device prototyping, electrical testing, high-fidelity neural signal acquisition, stimulator and sensor development, and advanced computational modeling. A fully integrated innovation environment built for end-to-end neuromodulation research. Explore Facility Non-Invasive Neuromodulation Laboratory (MnDRIVE Access)
- [Team - Old Version](https://thetntlab.com/team-old/) - Our Team Our Principal Investigator Dr. Rosana Esteller Professor, Biomedical Engineering Department, University of Minnesota. MnDRIVE Neuromodulation Scholar Co-founder, IntelliMedix Inc. (Key architect of the world’s first closed-loop brain-implantable neuromodulation device for epilepsy) Former Associate Director & Scientific Fellow, R&D Boston Scientific MNDrive Brain Conditions Profile UMN Faculty Profile LinkedIn Google Scholar ORCID Our Co-Principal
- [Research](https://thetntlab.com/research/) - Unifying Approach Across Our Four Pillars We build biomarker-driven, safety -constrained closed-loop neuromodulation by integrating multimodal sensing, computational modeling, control policy design, and IRB-based translational studies. Medical Areas of Active ResearchWe focus on a range of neurological conditions, particularly those that are high-impact and underserved. While our projects span biomarker discovery, computational modeling, smart clinical
- [Research - Old Version](https://thetntlab.com/research-old/) - Unifying Approach Across Our Four Pillars We build biomarker-driven, safety -constrained closed-loop neuromodulation by integrating multimodal sensing, computational modeling, control policy design, and IRB-based translational studies. AI/ML for Biomarker Discovery Computational Modeling Closed-Loop Control Smart Clinical Trials
- [Publications](https://thetntlab.com/publications/) - Publications Journal Publications Book Chapters Selected Conference Publications 2025, April 9th Spinal cord stimulation using time-dynamic pulses achieves longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain. Zhu C, Jeong KS, Edhi M, Rogness V, Saab CY, Esteller R. Frontiers in Pain Research, 6:1541078 2024, February 7th Absence of
- [Publications - Old Version](https://thetntlab.com/publications-old/) - Our Lab's Publications Journal Publications Book Chapters Selected Conference Publications 2025, April 9th Spinal cord stimulation using time-dynamic pulses achieves longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain. Zhu C, Jeong KS, Edhi M, Rogness V, Saab CY, Esteller R. Frontiers in Pain Research, 6:1541078 2024, February 7th
- [Innovations](https://thetntlab.com/innovations/) - Patents Selected Patents 2023 Automatic therapy adjustment based on internal and external sensing. Esteller R., Haddock A. J., Malekmohammadi M., & Zhang T. US-2023248977-A1. 2024, February 7th Automatic therapy adjustment based on sensors. Allavatam, V., Esteller, R., Haddock, A. J., & Malekmohammadi, M. AU-2023218273-A1. 2023 Method and apparatus for determining true neural activation changes. Esteller,
- [Innovations - Old Version](https://thetntlab.com/innovations-old/) - Our Lab's Patents Selected Patents 2023 Automatic therapy adjustment based on internal and external sensing. Esteller R., Haddock A. J., Malekmohammadi M., & Zhang T. US-2023248977-A1. 2024, February 7th Automatic therapy adjustment based on sensors. Allavatam, V., Esteller, R., Haddock, A. J., & Malekmohammadi, M. AU-2023218273-A1. 2023 Method and apparatus for determining true neural activation
- [Contact Us Old Version](https://thetntlab.com/contact/) - Get In Touch With Us Innovate Together Join Us in Advancing Neuroscience Please enable JavaScript in your browser to complete this form.Please enable JavaScript in your browser to complete this form.Volunteer Full NameFirstLastAgeEmail AddressWhy are you interested in participating in this research study?Eligibility: Are you 18 years old or older? (Yes/No)YesNoEligibility: Are you able to
- [Contact Us - SSB Version](https://thetntlab.com/contact-us-ssb-version/) - Get In Touch With Us Interested in collaborating/partnering with us? We work with industry teams to translate new neurotechnologies from concept to clinical validation. Our core capabilities include: Biomarker DiscoveryComputational Modeling Closed-loop control Smart clinical and preclinical (animal) trials Interested in joining as a lab researcher? Interested in participating in an active study? Innovate Together Join Us
- [AI/ML for Biomarker Discovery](https://thetntlab.com/ai-ml-for-biomarker-discovery/) - AI/ML For Biomarker Discovery Our lab leverages cutting-edge Artificial Intelligence (AI) and Machine Learning (ML) to transform subjective patient experiences into objective, measurable biomarkers. By integrating multi-modal data from neural and physiological sources, we develop predictive models that define "neural signatures" for complex conditions like drug-resistant epilepsy and chronic pain. Building on our PI’s prior
- [Research - Copy - Copy](https://thetntlab.com/research-copy-copy/) - Unifying Approach Across Our Four Pillars AI/ML for Biomarker Discovery Computational Modeling Closed Loop Control Smart and Optimized Clinical Trials Hamburger Toggle Menu We build biomarker-driven, safety -constrained closed-loop neuromodulation by integrating multimodal sensing, computational modeling, control policy design, and IRB-based translational studies. AI/ML For Biomarker DiscoveryThis pillar provides the biomarker and state-estimation layer that
- [Team - Copy](https://thetntlab.com/team-copy/) - The Team Principal Investigator Dr. Rosana Esteller Professor, Biomedical Engineering Department, University of Minnesota MnDRIVE Neuromodulation Scholar Co-found, InelliMedix Inc. (Key architect of the world's first closed-loop brain implantable neuromodulation device for epilepsy) Former Associate Director & Scientific Fellow, R&D Boston Scientific UMN Faculty Profile MNDrive Brain Conditions Profile LinkedIn Google Scholar ORCID Post-Doctoral Fellows
- [Closed-Loop Control](https://thetntlab.com/closed-loop-control/) - Our Closed-Loop Architecture A closed-loop system is an intelligent feedback loop designed to monitor a patient's biological state and adjust therapy automatically. Our architecture organizes this process into three integrated layers: Embedded LayerThis is the patient-side interface where an implanted neurostimulator records sensor data and adjusts manipulated variables to provide real-time therapy. Monitoring LayerThis layer
- [Research - Copy](https://thetntlab.com/research-copy/) - Unifying Approach Across Our Four Pillars We build biomarker-driven, safety -constrained closed-loop neuromodulation by integrating multimodal sensing, computational modeling, control policy design, and IRB-based translational studies. AI/ML For Biomarker DiscoveryThis pillar provides the biomarker and state-estimation layer that informs modeling and closed-loop control pillars.Besides advanced signal processing techniques, our lab leverages cutting-edge Artificial Intelligence (AI)
- [Smart Clinical Trials](https://thetntlab.com/smart-clinical-trials/) - Redefining Research: Smart & Optimized Clinical Trials We run IRB-based study protocols designed to maximize information per participant and accelerate iteration of neuromodulation parameters and biomarkers. “Smart/Optimized” refers to: (i) standardized clinical endpoints with digital capture (e.g., ePRO/eDiary) alongside objective measures, and (iii) analysis pipelines that support rapid phenotype/state characterization and patient-specific dose–response mapping. What
- [Computational Modeling](https://thetntlab.com/computational-modeling/) - Computational Modeling: A Bridge to Precision Medicine Our lab uses mathematical modeling to unify neural physiology, device physics, and clinical outcomes. As a newly launched lab, we build on our PI’s decades of prior research and translational development in closed-loop neuromodulation. We develop mechanistic and data-driven computational models of stimulation delivery and brain/spinal network response

## My Templates

- [Default Kit](https://thetntlab.com/?elementor_library=default-kit)
- [Research Subpage Template](https://thetntlab.com/?elementor_library=research-subpage-template) - Computational Modeling: A Bridge to Precision Medicine Our lab uses mathematical modeling to unify neural physiology, device physics, and clinical outcomes. As a newly launched lab, we build on our PI’s decades of prior research and translational development in closed-loop neuromodulation. We develop mechanistic and data-driven computational models of stimulation delivery and brain/spinal network response
- [Team Page](https://thetntlab.com/?elementor_library=team-page) - Our Team Principle Investigator Faculty Collaborators Post Doctoral Candidates PhD Students Masters Students Undergraduate Students Dr. Rosana Esteller Professor, Biomedical Engineering Department, University of Minnesota. MnDRIVE Neuromodulation Scholar Co-founder, IntelliMedix Inc. (Key architect of the world’s first closed-loop brain-implantable neuromodulation device for epilepsy) Former Associate Director & Scientific Fellow, R&D Boston Scientific Dr. Sandipan Pati
- [Publications](https://thetntlab.com/?elementor_library=publications) - Our Lab's Publications Journal Publications Book Chapters Selected Conference Publications 2025, April 9th Spinal cord stimulation using time-dynamic pulses achieves longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain. Zhu C, Jeong KS, Edhi M, Rogness V, Saab CY, Esteller R. Frontiers in Pain Research 6:1541078 2024, February 7th
- [Publication Card](https://thetntlab.com/?elementor_library=publication-card) - 2025 Spinal cord stimulation using time-dynamic pulses achieves longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain. Zhu C, Jeong KS, Edhi M, Rogness V, Saab CY, Esteller R. Frontiers in Pain Research
- [Hero Section NeuroTrans](https://thetntlab.com/?elementor_library=hero-section-neurotrans) - Intelligent Neurotechnology. Real Clinical Impact. Led by Dr. Rosana Esteller Transforming neuroscience, engineering, and clinical insight into devices and algorithms that adapt to the human body in real time. Meet Our Team Explore Our Research

## Elementor Header & Footer Builder

- [Global Footer](https://thetntlab.com/elementor-hf/global-footer/) - Menu Research Team Publications Innovations Facilities Contact Us UMN Biomedical Department TNT Lab Director: Prof. R. Esteller, Ph.D.
- [Top Menu Bar For Research Applicant Page](https://thetntlab.com/elementor-hf/top-menu-bar-for-research-applicant-page/)
- [Top Menu Bar For Dark Pages](https://thetntlab.com/elementor-hf/top-menu-bar-for-dark-pages-2/) - Menu Research Team Publications Innovations Facilities Contact Us
- [Top Menu Bar For Light Pages](https://thetntlab.com/elementor-hf/top-menu-bar-for-light-pages/) - Menu Research Team Publications Innovations Facilities Contact Us
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